SUBSTITUTED 5-(3,5-DIMETHYLISOXAZOL-4-YL)INDOLINE-2-ONES

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专利权人:

BEIGENE; LTD.

发明人:

REN, BO,任博,任博,ZHOU, CHANGYOU,周昌友,周昌友,WANG, HEXIANG,王鹤翔,王鶴翔

申请号：

TW103113521

公开号：

TW201538499A

申请日:

2014.04.14

申请国别(地区):

TW

年份:

2015

代理人:

摘要：

Disclosed are substituted 5-(3,5-dimethylisoxazol-4-yl)indoline-2-one compounds, pharmaceutical compositions comprising at least one such 4 substituted 5-(3,5-dimethylisoxazol-4-yl)indoline-2-one compound processes for the preparation thereof, and the use thereof for inhibiting BET family of bromodomains and for treating disorders mediated thereby, such as certain cancers.本發明係揭示一種經取代的5-(3,5-二甲基異唑-4-基)二氫吲哚-2酮化合物,包括至少一個4經取代的5-(3,5-二甲基異唑-4-基)二氫吲哚-2酮化合物之醫藥組成物,其製備方法,及其用於抑制布羅莫結構域之BET家族和治療由此引起疾病,如特定癌症之用途。

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中国工程科技知识中心

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