Disclosed are substituted5 (3 5 dimethylisoxazol 4 yl)indoline 2 one compounds pharmaceutical compositions comprising at least one such4substituted5 (3 5 dimethylisoxazol 4 yl)indoline 2 one compound processes for the preparation thereof and the use thereof for inhibiting BET family of bromodomains and for treating disorders mediated thereby such as certain cancers.