PROBLEM TO BE SOLVED: To scientifically reveal the base in which fermented products provide various bioactivities, while identifying the biologically active ingredients characteristically comprised in fermented products of Rhizopus strain, such as Ushikoshi bacteria, and quantifying specific activities thereof.SOLUTION: The present invention provides a pharmaceutical composition for the prevention, treatment, and alleviation of menopausal symptom, the composition containing a fermented product of Rhizopus bacteria containing as an active ingredient prostaglandin F2α, a novel production method of the fermented product of Rhizopus bacteria, and an evaluation method of bioactivity of the fermented product of Rhizopus bacteria which comprises measuring the content of prostaglandin F2α, and evaluating bioactivity based on the measured value.SELECTED DRAWING: Figure 3COPYRIGHT: (C)2017,JPO&INPIT【課題】牛越菌等のリゾプス属の菌株の発酵生産物に特徴的に含まれる生理活性成分を特定し、その比活性を定量化するとともに、発酵生産物が様々な生理活性をもたらす基盤を科学的に明らかにすること。【解決手段】プロスタグランジンF2αを活性成分として含有するリゾプス菌の発酵生産物を含む、更年期障害の予防・治療・軽減のための医薬組成物、リゾプス菌の発酵生産物の新規な製造方法、及び、リゾプス菌の発酵生産物の生理活性の評価方法であって、プロスタグランジンF2αの含有量を測定し、該測定値に基づき生理活性を評価することを含む、前記評価方法等。【選択図】図3
