您的位置: 首页 > 农业专利 > 详情页

ПОЛИМЕРНЫЕ НАНОЧАСТИЦЫ, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ ДОСТАВКИ ЛЕКАРСТВЕННЫХ СРЕДСТВ
专利权人:
ИНСТИТУТ КИМИК ДЕ САРРИЯ (ES)
发明人:
ГОМЕС Сальвадор Боррос (ES),ДИ МАУРО Примьяно Пио (ES)
申请号:
RU2013154422/15
公开号:
RU2013154422A
申请日:
2012.05.09
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A nanoparticle comprising a block copolymer and optionally one or more active substances, which: (i) the block copolymer comprises blocks A and D (ii) block A consists of a first polymer comprising monomer units B and C, while B is an aliphatic unit dicarboxylic acid, wherein the total number of carbon atoms ≤30, and C is a link or dihydroxyl diaminomonomerom (iii) block D is composed of a second polymer comprising a hydrocarbon chain containing ester or ether linkages, with a hydroxyl number ≥10.2. A nanoparticle according to claim 1, wherein the block A has the formula - [(BC) -B] -, where n is a numerical index of at least one independently selected for each block A.3. A nanoparticle according to claim 1, wherein the monomer unit C is an aliphatic straight chain diol comprising 4-10 atoms ugleroda.4. A nanoparticle according to claim 1, wherein the monomer unit C is 1,8-oktandiolom.5. A nanoparticle according to claim 1, wherein the monomer unit B comprises 4-10 ugleroda.6 atoms. A nanoparticle according to claim 5, wherein the monomer unit B comprises 5-10 ugleroda.7 atoms. A nanoparticle according to claim 1, wherein the polymer D is selected from the group consisting of polyethylene glycols, polyamidoamines, polyamines, polyols and kombinatsiy.8. A nanoparticle according to claim 1, which comprises at least one active veschestvo.9. A nanoparticle according to claim 1, wherein the at least one active substance had logP value from -1.0 to +5,6.10. A nanoparticle according to claim 1, wherein the at least one active substance selected from the group consisting of docetaxel and paklitaksel.11. A nanoparticle according to claim 1, which comprises one or more binding agents suitable for covalent attachment to said nanoparticle1. Наночастица, включающая блоксополимер и необязательно одно или несколько активных веществ, в которой:(i) блоксополимер включает блоки А и D(ii) блок А состоит из первого полимера, включающего мономерные звенья В и С, при этом звено В явля
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充