Howard Glenn Damude,Quinn Qun Zhu,Peter John Gillies,Daniel Joseph Macool,Stephen K. Picataggio,Dana M. Walters Pollak,James John Ragghianti,Zhixiong Xue,Narendra S. Yadav,Hongxiang Zhang
申请号：
US13675144
公开号：
US20130123361A1
申请日:
2012.11.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 10% arachidonic acid (ARA, an ω-6 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases, and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of ARA. Production host cells are claimed, as are methods for producing ARA within said host cells.
