COMPOSÉS PURINE UTILISÉS EN TANT QUE PROMÉDICAMENTS DES ANTAGONISTES DU RÉCEPTEUR A2B DE L'ADÉNOSINE, LEUR PROCÉDÉ DE PRÉPARATION ET LEURS APPLICATIONS MÉDICALES
The present disclosure relates to purine compounds of formula (I) or formula (II) or its tautomers, polymorphs, stereoisomers, solvates or a pharmaceutically acceptable salts, or pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by thereof as A2B adenosine receptor antagonists. {Formulas should be inserted here} The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases and disorders that may be susceptible to improvement by the mediation of adenosine A2B receptor. Such conditions include, but are not limited to, asthma, chronic obstructive pulmonary disorder, angiogenesis, pulmonary fibrosis, emphysema, allergic diseases, inflammation, reperfusion injury, myocardial ischemia, atherosclerosis, hypertension, congestive heart failure, retinopathy, diabetes mellitus, obesity, inflammatory gastrointestinal tract disorders including inflammatory bowel disease, sickle cell disease, and/or autoimmune diseases. and to their use in treating mammals for various disease states, such as gastrointestinal disorders, immunological disorders, hypersensitivity disorders, neurological disorders, and cardiovascular diseases due to both cellular hyperproliferation and apoptosis, and the like. The present disclosure also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.L'invention concerne des composés purine de formule (I) ou de formule (II) ou leurs tautomères, variantes polymorphiques, stéréoisomères, solvants ou sels pharmaceutiquement acceptables, ou encore des compositions pharmaceutiques les contenant, ainsi que méthodes pour traiter des états et des maladies dont la médiation est assurée par des antagonistes du récepteur A2B de l'adénosine. Les composés selon l'invention servent à traiter, prévenir ou supprimer des maladies et troubles pouvant être améliorés par la médiation du récepteur A2B de l'adénosine. Parmi
