Structural formula (I) and N- hydroxy derivatives, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, pulmonary fibrosis, and especially the liver, autoimmune disorders, the present invention, inflammatory disease, their use for the treatment and prevention of fibrosis cardiovascular disease, neurodegenerative diseases, cancer, respiratory and / or disease.本発明は、構造式(I)のN-ヒドロキシアミド誘導体及び、特に多発性硬化症、関節炎、気腫、慢性閉塞性肺疾患、肝臓及び肺線維症を含む、自己免疫障害、炎症性疾患、循環器疾患、神経変性疾患、癌、呼吸器疾患及び線維症の治療及び/又は予防のためのその使用に関する。