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DERIVADOS DE AZETIDINA Y CICLOBUTANO COMO INHIBIDORES DE JAK
- 专利权人:
- INCYTE CORPORATION
- 发明人:
- RODGERS, JAMES D.,YUN-LONG, LI,SHEPARD, STACEY,XIA, MICHAEL,PINGLI, LIU,ZHOU, JIACHENG,MELONI, DAVID
- 申请号：
- PE0008892013
- 公开号：
- PE00992014A1
- 申请日:
- 2009.03.11
- 申请国别(地区):
- PE
- 年份:
- 2014
- 代理人:
- 摘要：
- Relating to compounds of jak inhibitors: cyclopropylsulfonyl - 1 - 3 - [4 - (7H pyrrolo [2,3-d] pyrimidin-4-yl) - 1H - azetidin pyrazol-1-yl] - 3 - ilacetonitrilo, propilsulfonil {1 - - 3 - [4 - (7H pyrrolo [2,3, - d] pyrimidin-4-yl) - 1H pyrazol-1-yl] - 3 - azetidin {il} acetonitrile, 1 - [(1 - methyl - 3 - 1H pyrazole - il) sulfonyl] - 3 - [4 - (7H Pyrrolo [2,3-d] pyrimidin-4-yl) - 1H pyrazol-1-yl] - 3 - azetidin il} acetonitrile3 - (cyanomethyl) - 3 - [4 - (7H pyrrolo [2,3-d] pyrimidin-4-yl) - 1H pyrazol-1-yl] ciclobutanocarbonitrilo and ethylsulfonyl {1 - - 3 - [4 - (7H pyrrolo [2,3-d] pyrimidin-4-yl) - 1H - azetidin pyrazol-1-yl] - 3 - il} acetonitrile or a pharmaceutically acceptable Salt thereof. It also relates to a Pharmaceutical composition comprising these compounds for oral or topical AdministrationREFERIDA A LOS COMPUESTOS INHIBIDORES DE JAK: 1-CICLOPROPILSULFONIL-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]AZETIDIN-3-ILACETONITRILO, {1-PROPILSULFONIL-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]AZETIDIN-3-IL}ACETONITRILO, {1-[(1-METIL-1H-PIRAZOL-3-IL)-SULFONIL]-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]AZETIDIN-3-IL}ACETONITRILO, 3-(CIANOMETIL)-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]CICLOBUTANOCARBONITRILO Y {1-ETILSULFONIL-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]AZETIDIN-3-IL}ACETONITRILO O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS PARA ADMINISTRACION TOPICA U ORAL
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
