UNIMOLECULAR NANOPARTICLES FOR EFFICIENT DELIVERY OF THERAPEUTIC CATIONIC PEPTIDES

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专利权人:

Wisconsin Alumni Research Foundation

发明人:

Shaoqin GONG,Wei XU,Yuyuan WANG,Fabao LIU

申请号：

US15892140

公开号：

US20180235897A1

申请日:

2018.02.08

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.

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中国工程科技知识中心

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http://www.ckcest.cn/home/