Treatment of varying degrees of cognitive impairment associated with Alzheimers disease with a combination of a phosphodiesterase 4 inhibitor and an acetylcholinesterase inhibitor, including roflumilast and donepezil hydrochloride.本發明係關於以磷酸二酯酶4抑制劑及乙醯膽鹼酯酶抑制劑之組合(包括羅氟司特(roflumilast)及鹽酸多萘哌齊(donepezil))治療與阿茲海默氏病(Alzheimers disease)相關聯的各種程度的認知損傷。