The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with fludarabine and/or mitoxantrone for the treatment of cancer, especially to the combination therapy of CD20 expressing cancers with an afucosylated humanized B-Ly1 antibody with fludarabine and/or mitoxantrone.本發明係關於非典型岩藻醣化抗CD20抗體與氟達拉濱(fludarabine)及/或米托蒽醌(mitoxantrone)用於治療癌症之組合療法,尤其係關於使用非典型岩藻醣化人類化B-Ly1抗體與氟達拉濱及/或米托蒽醌治療表現CD20之癌症的組合療法。