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Pyran dervatives as CYP11A1 (cytochrome P450 monooxygenase 11A1) inhibitors
专利权人:
Orion Corporation
发明人:
David Din Belle,Mikko Mäkelä,Mikko Passiniemi,Pekka Pietikäinen,Petteri Rummakko,Eija Tiainen,Matti Vaismaa,Gerd Wohlfahrt
申请号:
US16472377
公开号:
US10717726B2
申请日:
2017.12.21
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Compounds of formula (I)wherein R1, R2, R3, R4, R5, R23, R24, L, A and B are as defined in claim 1, or pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as cytochrome P450 monooxygenase 11A1 (CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroid receptor, particularly androgen receptor, dependent diseases and conditions, such as prostate cancer.
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