Theodore J. Nitz,Christian Montalbetti,Richard Mears,Xinjie Gai,Edward Glenn
申请号：
US12513454
公开号：
US20120046291A1
申请日:
2007.11.02
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention concerns novel pharmaceutically active triterpene derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the compounds. Specifically, the compounds are derivatives of betulinic acid having substitutions at one or more of the C-3, C2-8 and C-19 positions as further described herein. The novel compounds are useful as antiretroviral agents. In particular, the novel compounds are useful for the treatment of Human Immunodeficiency Virus (HIV).
