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Methods of treating S. aureus-associated diseases
专利权人:
LLC;MedImmune
发明人:
Sellman, Bret,Tkaczyk, Christine,Hamilton, Melissa,Hua, Lei
申请号:
AU2013341421
公开号:
AU2013341421A1
申请日:
2013.11.05
申请国别(地区):
AU
年份:
2015
代理人:
摘要:
The present invention provides for methods of preventing and/or treating S. aureusassociated bacteremia and sepsis, and methods for preventing and/or treating S. aureus associated pneumonia in immunocompromised patients using anti-S. aureus alpha-toxin (antiAT) antibodies. Also provided are methods of reducing S. aureus bacterial load in the bloodstream or heart of a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof. Methods of reducing S. aureus bacterial agglutination and/or thromboembolic lesion formation in a mammalian subject comprising administering to the subject an effective amount of an isolated anti-S. aureus alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, are also provided. Also provided are methods of preventing or reducing the severity of S. aureus -associated pneumonia in an immunocompromised mammalian subject.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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