each active pharmaceutical ingredient as metoprolol or a pharmaceutically acceptable salt thereof including a 2 a plurality of pellets A and B of the species, wherein the pellets A is after four hours in the test medium, pH 6.8 in an amount sufficient to result in the active pharmaceutical ingredient release profile according to USP has a release rate of less than 20%, 20 to 40 wt. % of ethyl acrylate, 60 to 80% by weight of methyl methacrylate, and 0 or 5, at least one polymerized from methacrylic acid or acrylic acid of less than% by weight (meth) acrylate polymer compounds formed of the copolymer 30% coated with a coating layer comprising at least, pellet B is not coated, or, or is coated with a coating layer, pH active pharmaceutical ingredient release profile of the USP with the active pharmaceutical ingredient release rate of more than 40% after 4 hours at 6.8 of the test medium and will indicate, 40% of the Universal Storage Platform (v / v) ethanol is metoprolol release rate of the pellets A in the test medium is added the pH 1.2 a * not more than 15% after 15 minutes, - 15% or less than 40% in 30 minutes and, 40% of the Universal Storage Platform (v / v) and the ethanol is metoprolol release rate of the pellets B in test medium was added a pH 1.2 is by 15% over 15 minutes, - more than 40% in 30 minutes, the pellets A and B more than 25% after - 1 hour at the test media of a pH 6.8 * 4 20 - 40% after a period of time, * 8 after time of 40 to 60%, the multi-particulate pharmaceutical composition according to USP has a more than 80% of the release rate after - 20 hours a combination of active pharmaceutical ingredient has a multi-particulate pharmaceutical compositions present in the multi-particulate pharmaceutical composition that results in relation to the release profile described.각각 활성 제약 성분으로서 메토프롤롤 또는 그의 제약상 허용되는 염을 포함하는 2종의 펠릿 A 및 B를 다수 포함하고, 여기서 펠릿 A는 pH 6.8의 시험 매체에서 4시간 후에 20% 미만의 방출률을 갖는 USP에 따른 활성 제약 성분 방출 프로파일을 초래하는 충분한 양으로, 20 내지 40 중량%의 에틸 아크릴레이
