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Systemic pharmaceutical forms with controlled release and improved stability
专利权人:
MARIA CLEMENTINE MARTIN KLOSTERFRAU VERTRIEBSGESELLSCHAFT MBH
发明人:
MIETHING, HOLGER,GREVE, HARALD
申请号:
ES13700054
公开号:
ES2552081T3
申请日:
2013.01.04
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Pharmaceutical form containing monoterpene for peroral administration in the form of a capsule, in particular in the form of a capsule with a core / shell structure with a multilayer shell, the capsule having from inside to outside the following structure: (a) a capsule core , which contains at least one active substance containing monoterpene, in particular at least one monoterpene, (b) a first capsule shell, which surrounds the capsule core, in particular that directly surrounds the capsule core, which gives structure and / or which forms and (c) a second capsule shell, which surrounds the first capsule shell, in particular that directly surrounds the first capsule shell, preferably in the form of a coating, in particular in the form of a coating resistant to gastric juices, but enteric, the second capsule shell comprising at least two components (contents or constituents), being formed a first make up te ("component 1") based on alginic acid or its physiologically compatible salts or esters and a second component ("component 2") based on cellulose, the pharmaceutical form having a weight percentage of the second capsule shell, depending of the pharmaceutical form, in the range of 0.5 to 4% by weight.Forma farmacéutica que contiene monoterpeno para la administración peroral en forma de una cápsula, en particular en forma de una cápsula con estructura de núcleo/envuelta con envuelta multicapa, presentando la cápsula de dentro a fuera la siguiente estructura: (a) un núcleo de cápsula, que contiene al menos un principio activo que contiene monoterpeno, en particular al menos un monoterpeno, (b) una primera envuelta de cápsula, que rodea el núcleo de cápsula, en particular que rodea directamente el núcleo de cápsula, que da estructura y/o que da forma y (c) una segunda envuelta de cápsula, que rodea la primera envuelta de cápsula, en particular que rodea directamente la primera envuelta de cápsula, preferentemente en forma de un recubrimiento, en particular en forma d
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