A palatable thermal insulation baby bottle, including a bottle body made of glass material, one end of the bottle body is the bottle mouth, for a cap or a nipple to fix on. The bottle body has an inner bottle body and an outer bottle body, and the inner bottle body has a hollow liquid storage space in its interior. The bottle body has a vacuum layer between the outer bottle body and the inner bottle body. When necessary, a mesh or full-covering insulation layer may be further disposed in the vacuum layer on at least one of the outer peripheral wall of the inner bottle or the outer peripheral wall of the outer bottle body. The thermal insulation baby bottle can reduce and slow down the heat conduction and convection by the abovementioned bottle sandwich structure therefore, facilitating to check the amount of liquid in the liquid storage space from the outside and to have a desired effect of thermal insulation for a certain period of time.