KOSSEN, Karl,SEIWERT, Scott,SEREBRYANY, Vladimir,RUHRMUND, Donald,BEIGELMAN, Leonid,RAVEGLIA, Luca,VALLESE, Stefania,BIANCHI, Ivana,HU, Tao
申请号：
ES09759347
公开号：
ES2567283T3
申请日:
2009.06.03
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula II ** Formula ** in which R1 is selected from the group consisting of hydrogen； C1-C10 alkyl substituted or unsubstituted； substituted or unsubstituted cycloalkyl； C2-C10 substituted or unsubstituted alkenyl； cyano； sulfonamide； halo； substituted or unsubstituted aryl； substituted or unsubstituted alkenylenearyl； and substituted or unsubstituted heteroaryl； R2 is selected from the group consisting of substituted aryl； unsubstituted heteroaryl and heteroaryl substituted with one or more substituents selected from halo, alkyl, alkenyl, OCF3, NO2, CN, OH, alkoxy, haloalkoxy, amino, CO2H, CO2 alkyl and heteroaryl, wherein the heteroaryl is selected from the group that it consists of thienyl, furyl, oxazolyl, quinolyl, thiophenyl, isoquinolyl, indolyl, triazinyl, triazolyl, isothiazolyl, isoxazolyl, imidazolyl, benzothiazolyl, pyrazinyl, pyrimidinyl, thiazolyl and thiadiazolyl； R3 is selected from the group consisting of hydrogen； substituted or unsubstituted aryl； substituted or unsubstituted alkenylenearyl； substituted or unsubstituted heteroaryl； C1-C10 alkyl substituted or unsubstituted； C2-C10 substituted or unsubstituted alkenyl； haloalkyl； Not me； and hydroxy； R4 is selected from the group consisting of hydrogen； C1-C10 alkyl substituted or unsubstituted； haloalkyl； cyano； alkoxy； substituted or unsubstituted aryl； C2-C10 substituted or unsubstituted alkenyl； substituted or unsubstituted alkenylenearyl； and substituted or unsubstituted heteroaryl； and X1, X2, X3, X4 and X5 are independently selected from the group consisting of hydrogen； C1-C10 alkyl substituted or unsubstituted； C2-C10 substituted or unsubstituted alkenyl； halo； hydroxyl； Not me； substituted or unsubstituted aryl； substituted or unsubstituted cycloalkyl； thioalkyl； alkoxy； haloalkyl； haloalkoxy； alkoxyalkyl； cyano； aldehyde； alkylcarbonyl； amido； haloalkylcarbonyl； sulfonyl； and sulfonamide； or X2 and X3 together form a ring of 5 or 6 members comprising -O (CH2) nO-, where n
