KIM, In Woo (KR),КИМ, Ин У (KR),YOO, Ja Kyung (KR),ЙОО, Дза Киунг (KR),KIM, Ji Duck (KR),КИМ, Чи Дук (KR),JUN, Sun Ah (KR),ЧОН, Сон А (KR),LEE, Jun Hee (KR),ЛИ, Чон Хи (KR)
申请号：
RU2019123998
公开号：
RU0002726632C1
申请日:
2018.03.19
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: present invention relates to a compound of chemical formula 1, having inhibitory activity on janus-kinase (JAK3) and Bruton tyrosine kinase (BTK), or a pharmaceutically acceptable salt thereof. In one embodiment, in chemical formula 1, X is O； A is a ring selected from a group consisting of benzothiazole, isothiazole, isoxazole, pyrazole, pyrrole, thiazole, thiophene and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine； R1 denotes hydrogen； C1-4 alkyl, unsubstituted or substituted with one substitute selected from a group consisting of C1-4 alkoxy and N(C1-4 alkyl)2； C1-4 alkoxy； C1-4 haloalkyl； C3-6 cycloalkyl； N(C1-4 alkyl)2； pyrazolyl unsubstituted or substituted with one or two C1-4 alkyl groups； or , where Y1 is NH, N(C1-4 alkyl) or O； Y2 is CH or N； L is a bond, C1-4 alkylene or CO； R2 denotes hydrogen, C1-4 alkyl or halogen, and R3 is C1-4 alkyl substituted with halogen； C2-4 alkenyl unsubstituted or substituted with halogen； or C2-4 alkynyl. In another embodiment in chemical formula 1 X is O； A is a ring selected from the group consisting of benzene and pyridine； R1 denotes hydrogen； C1-4 alkyl, unsubstituted or substituted with one substitute selected from a group consisting of C1-4 alkoxy and N (C1-4 alkyl)2 ； C1-4 alkoxy； C1-4 haloalkyl； C3-6 cycloalkyl； N(C1-4 alkyl)2； pyrazolyl unsubstituted or substituted with one or two C1-4 alkyl groups； or , where Y1 is NH, N (C1-4 alkyl) or O； Y2 is CH or N； L is a bond, C1-4 alkylene or CO； R2 is halogen, and R3 is C1-4 alkyl substituted with halogen； C2-4 alkenyl unsubstituted or substituted with halogen； or C2-4 alkynyl. Present invention also refers to a pharmaceutical composition containing said compounds or their pharmaceutically acceptable salts.[chemical formula 1].EFFECT: pharmaceutical composition can be used for preventing or treating an inflammatory disease, an autoimmune disease, a proliferative disease, a hyperproliferative disease, an immuno-mediated disease, cancer or tumour.9 c
