KI HWAN CHANG,KWANG-WON HONG,SE-HO KIM,Wong-Won SHIN
申请号：
BR112015000474
公开号：
BR112015000474A2
申请日:
2013.07.08
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
antibody composition for the prevention or treatment of hepatitis b mutant virus infection by providing an antibody that binds to the hepatitis b virus (hbv) surface antigen (hbsag) ) to neutralize hepatitis b virus. the surface antigen binding site of the antibody has been shown to play a very important role in viral replication, and when a mutation in the site occurs, replication is significantly inhibited, so at least the hbv virus cannot cause a mutation in the site. In the present invention, it has been confirmed by the use of a patient-derived virus that the antibody of the present invention binds to the hepatitis b ymdd mutant virus produced by conventional viral replication inhibitors. , or g145r hbsag mutants to which plasma-derived hbig (hepatitis b immunoglobulin) do not bind. The antibody of the present invention has the ability to bind not only to wild-type hepatitis B virus but also to hepatitis B mutant viruses having a polymerase ymdd mutant and a mutation. surface antigen g145r, as well as various patient-derived mutant viruses. The antibody of the present invention can be effectively used for the prevention or treatment of infections with not only wild-type hepatitis B virus, but also hepatitis mutant viruses. B. 1/1resumo composi‚ìo de anticorpo para a preven‚ìo ou tratamento de infec‚ìo por vêrus mutante da hepatite b, provendo um anticorpo que se liga ao ant’geno de superf’cie (hbsag) do v’rus da hepatite b (hbv) para neutralizar o v’rus da hepatite b. o s’tio de liga�‹o ao ant’geno de superf’cie do anticorpo demonstrou desempenhar um papel muito importante na replica�‹o viral, e quando uma muta�‹o no s’tio ocorre, a replica�‹o viral ž significativamente inibida, e, assim, pelo menos o v’rus hbv n‹o pode causar uma muta�‹o no s’tio. na presente inven�‹o, foi confirmado pelo uso de um v’rus derivado de paciente que o anticorpo da presente inven�‹o se liga ao v’rus mutante ymdd da hepatite b, produzido por inibidores de replica�‹o viral convencion
