The present invention relates to a method for the production of a biocompatible matrix the method comprising: a) providing a composition comprising at least one biopolymer b) extruding the composition into a layer through a slit onto a surface, wherein the slit moves over the surface c) optionally freezing the layer d) optionally repeating the process to add one or more further layers e) freezing the composition or compositions after extrusion and f) optionally drying the frozen composition, wherein preferably the surface can be cooled. The invention further relates to a biocompatible matrix obtainable by the method as well as to the use of a matrix obtainable by the method for medical or cosmetic purposes. Moreover, the present invention also relates to a device for the production of a biocompatible matrix, comprising: a) a temperature controlled surface b) an extruding means with a slit positioned above the surface c) means for extruding a composition through the slit and d) means for moving the slit and/or the surface.本發明係關於生物相容基質的製造方法,該方法包含:a)提供包含至少一生物高分子的組成物;b)透過狹縫擠製該組成物至表面上以形成層體,其中狹縫在表面上方移動;c)可選地將層體冷凍;d)可選地重複上述步驟,以增加一或多個後續層體;e)在擠製後將一或多種組成物冷凍;以及f)可選地乾燥冷凍的組成物,其中較佳地該表面可被冷卻。本發明係進一步關於由該方法所得的生物相容基質以及由該方法所得的基質用於醫藥或化妝品目的的用途。再者,本發明亦關於用於製造生物相容基質的裝置,其包含:a)溫度控制面;b)具有位於該表面上的狹縫之擠製手段;c)用於透過狹縫擠製組成物的手段;以及d)用於移動狹縫及/或表面的手段。1‧‧‧擠製裝置1.1‧‧‧進入口1.2‧‧‧狹縫1.3‧‧‧擠製裝置的移動2‧‧‧模具2.1‧‧‧底部表面3‧‧‧裝置3.1‧‧‧馬達3.2‧‧‧表面
