The present invention provides a process for preparing a modified release solid oral pharmaceutical composition comprising cyclobenzaprine or salts thereof. In particular, the present invention relates to a process for preparing modified release solid oral pharmaceutical composition comprising a core comprising cyclobenzaprine or salts thereof and one or more release modifying polymers, which core is coated with one or more water soluble release modifying polymers； wherein the coating is devoid of water insoluble polymers. The composition may provide extended and specific release of cyclobenzaprine or salts thereof to achieve therapeutically effective plasma concentration over a period of 24 hours to treat muscle spasm associated with painful musculoskeletal conditions when administered to a patient in need thereof. The invention also includes process of preparing such composition.
