BIALY, Laurent,PERNERSTORFER, Josef,WIRTH, Klaus,STEINMEYER, Klaus,HESSLER, Gerhard
申请号：
ES11757271
公开号：
ES2559221T3
申请日:
2011.09.12
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula I, ** Formula ** in which A>； = aryl (C6-C10) or a five-membered or six-membered heteroaryl, comprising 1-3 heteroatoms selected from the group N, O and S, wherein aryl and heteroaryl are optionally substituted with 1-3 substituents independently selected from F, Cl, Br, (C1-C6) alkyl, (C1-C6) alkyl-oxy-, (C1-C6) alkyl -S-, NC-, (C1-C6) alkyl - OC (O) -, (C1-C6) alkyl -SO2-, (C1-C6) alkyl-oxy-C1-C6 alkyl - or R12R13N-C (O) - , in which one or more hydrogen atoms of the alkyl moieties may be replaced by fluorine； R1>； = R10-C (O) -, R11-(C1-C6) alkyl -, cycloalkyl (C3-C6), (C1-C6) alkyl -SO2- or R12R13N-C (O) -alkyl (C1-C6) ) -, in which one or more hydrogen atoms of the alkyl moieties may be replaced by fluorine； R2>； = H, OH, (C1-C6) alkyl, (C1-C6) alkyl-oxy-, (C1-C6) alkyl-C (O) O-； R3>； = H, (C1-C6) alkyl -； R4>； = H, F, (C1-C6) alkyl, in which one or more hydrogen atoms of the alkyl moiety may be replaced by fluorine； R5>； = H, F, (C1-C6) alkyl, in which one or more hydrogen atoms of the alkyl moiety may be replaced by fluorine； R6 to R9 are each independently selected from H, F, Cl, Br, NC-, (C1-C6) alkyl, (C3-C6) cycloalkyl, (C1-C6) alkyl -SO2-, (C1-C6) alkyl -OC (O) -, (C1-C6) alkyl-oxy-, (C1-C6) -S- alkyl, in which one or more hydrogens of the alkyl moieties may be replaced by fluorine； R10>； = H, (C1-C6) alkyl, (C3-C6) cycloalkyl, (C1-C6) alkyl-oxy-, (C1-C6) alkyl -S-, HO-(C1-C6) alkyl, alkyl (C1-C6) -O-(C1-C6) alkyl -, cycloalkyl (C3-C6) -alkyl (C1-C6) - or R12R13N-, in which one or more hydrogens of the alkyl moieties may be replaced by fluorine, and R11>； = H, (C3-C6) cycloalkyl, OH, (C1-C6) -oxy- or (C1-C6) -S- alkyl, in which one or more hydrogen of the alkyl moieties may be replaced by fluorine； R12 and R13 are each independently H or (C1-C6) alkyl； and / or in a stereoisomeric form of the compound of the formula I and / or mixtures of these forms, and / or a physiologically tolerated salt of the compounds of form
