Ports, such as the ports of ported catheters or of female luer fittings, can be configured to include an antimicrobial septum for disinfecting devices that are attached to the ports. The antimicrobial septum can be positioned within the lumen of the port. The lumen can include an annular recess for securing the antimicrobial septum in place during use. The antimicrobial septum can include an antimicrobial lubricant which transfers onto a device, such as a male luer, as the device passes through the septum thereby killing any microbes that may be present on the surfaces of the device. The antimicrobial septum can be configured in various shapes including a continuous disk shape, a ring shape, or an elongated ring or tube shape. When configured as a ring or tube shape, the inner surfaces of the antimicrobial septum may contain slits or grooves. The slits or grooves can facilitate the compression of the septum as a device passes through it, while also increasing the surface area of the septum on which antimicrobial lubricant can be contained.
