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Β-L-2'-DESOXINUCLEÓSIDOS PARA TRATAMENTO DE ESTIRPES RESISTENTES DE VHB
专利权人:
NOVARTIS AG
发明人:
JEAN-PIERRE SOMMADOSSI,DAVID STANDRING,APRIL L.PATTY,MARIA SEIFFER
申请号:
PT03770334
公开号:
PT1572095E
申请日:
2003.09.15
申请国别(地区):
PT
年份:
2015
代理人:
摘要:
It has been discovered that &bgr;-L-2′-deoxynucleosides are active against drug-resistant hepatitis B virus with mutations. A method for treating lamivudine resistant HBV (M552V) in a host is provided that includes administering a &bgr;-L-2′-deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug. In addition, a method for preventing lamivudine resistant HBV (M552V) mutation from occurring in a naïve host is provided that includes administering a &bgr;-L-2′-deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug. A method for preventing and/or suppressing the emergence of the HBV double mutant (L528M/M552V) in a host is also provided that includes administering a &bgr;-L-2′-deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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