1- {2- [4- (2-amino-5-chloro-3-pyridinyl) phenoxy] -5-pyrimidinyl} -3- [2- (methylsulfonyl) -5- (trifluoromethyl) phenyl] urea salt thereof , pharmaceutical composition comprising them and their use for cancer treatment
JUN TAKEUCHI,KAZUYA HASHIMURA,MASAHIRO IKURA,MASATO HIGASHINO,SATOSHI ITADANI,TAKESHI NAGAURA,TETSUYA YASUHIRO
申请号：
BR122017003188
公开号：
BR122017003188A2
申请日:
2014.02.18
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
1- {2- [4- (2-amino-5-chloro-3-pyridinyl) phenoxy] -5-pyrimidinyl} -3- [2- (methylsulfonyl) -5- (trifluoromethyl) phenyl] urea salt thereof A pharmaceutical composition comprising them and their use for cancer treatment The present invention provides the compound 1- {2- [4- (2-amino-5-chloro-3-pyridinyl) phenoxy] -5-pyrimidinyl} -3 - [2- (methylsulfonyl) -5- (trifluoromethyl) phenyl] urea, a salt of this compound, as well as a pharmaceutical composition comprising both the compound and its salt as an active ingredient. The present invention also relates to or use of this compound and its salt for the manufacture of a prophylactic and / or therapeutic agent for the treatment of cancer, such as prostate cancer, pancreatic cancer, breast cancer, blood cancer, gland cancer. thyroid, cervical cancer, neuroblastoma or lung cancer.composto 1-{2-[4-(2-amino-5-cloro-3-piridinil)fenóxi]-5-pirimidinil}-3-[2-(metilsulfonil)-5-(trifluorometil)fenil]ureia, sal deste, composição farmacêutica compreendendo-os e uso destes para o tratamento de câncer a presente invenção fornece o composto 1-{2-[4-(2-amino-5-cloro-3-piridinil)fenóxi]-5-pirimidinil}-3-[2-(metilsulfonil)-5-(trifluorometil)fenil]ureia, um sal deste composto, assim como uma composição farmacêutica compreendendo tanto o composto quanto seu sal como um ingrediente ativo. a presente invenção também está relacionado ou uso deste composto e de seu sal para a fabricação de um agente profilático e/ou terapêutico para o tratamento de câncer, tal como câncer de próstata, câncer pancreático, câncer de mama, câncer sanguíneo, câncer da glândula tiroide, câncer de colo, neuroblastoma ou câncer de pulmão.
