Timothy C. Hoey,Ann M. Kapoun,Min Wang,Tzu-Ling Tang Lin,Jennifer Anne Cain,Jakob Dupont
申请号：
US14429497
公开号：
US20150232570A1
申请日:
2013.09.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
NOTCH1-binding antibodies and methods of using the antibodies for treating hematologic cancers are disclosed. Methods of using antibodies that bind to a non-ligand binding membrane proximal region of the extracellular domain of human NOTCH1 and methods of treating chronic lymphocytic leukemia (CLL), hairy cell leukemia, chronic myelogenous leukemia (CML), nonHodgkin lymphoma, diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), or cutaneous T-cell lymphoma (CTCL) in a subject, comprising administering a therapeutically effective amount of a NOTCH1-binding antibody to the subject are also disclosed. Methods of identifying subjects suitable for such treatment methods are further disclosed.
