Stephen C. Lee,Wu Lu,Leonard J. Brillson,Gregg A. Hadley,Patrick Adams,Ronald P. Pelletier,Paul R. Berger
申请号：
US13747921
公开号：
US20130204107A1
申请日:
2013.01.23
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed are field effect transistor-based (FET-based) sensors for the rapid and accurate detection of analytes both in vivo and in vitro. The FET-based sensors can include a substrate, a channel disposed on the substrate, a source electrode and a drain electrode electrically connected to the channel, and a recognition element for an analyte of interest immobilized on the surface of the channel via a linking group. The distance between the recognition element and the channel can be configured such that association of the analyte of interest with the recognition element induces a change in the electrical properties of the channel. In this way, an analyte of interest can be detected by measuring a change in an electrical property of the channel. Also provided are devices, including probes and multi-well plates, incorporating the FET-based sensors.
