JANSEN, TIMOTHY,MARCONI, JENNIFER MICHELLE,ALLA, DANILKOVITCH,SAMSON, TOM,JIN-QIANG KUANG,DANA YOO
申请号：
ARP110100507
公开号：
AR080220A1
申请日:
2011.02.18
申请国别(地区):
AR
年份:
2012
代理人:
摘要：
Placental Products comprising a inmunocompatible amniotic membrane. These products may contain criopreservarse placental cells and viable Therapeutic once thawed. The placental products of this are helpful to promote Healing.Claim 1: a placental product, characterized in that it comprises an amniotic Membrane, where the amniotic membrane. Includes Therapeutic cells viable； and is substantially free of Functional CD14 + macrophages； and Optionally, where cells are viable Therapeutic n Activa with relation to the amniotic membrane.Claim 3: The placental product of claim 1, wherein the amniotic Membrane comprises One, two or three layers selected from a compact Layer, a Spongy layer and a layer of fibroblasts.Claim 1: The placental product of claim 1, wherein a viable Therapeutic cells comprise one or more of the following types of cells: MSC； fibroblasts； epithelial cells； stromal cells； and e epitel cells and stromal cells. Acknowledged.Claim: The placental Product 26 of claim 24, wherein approximately about 40% and 92.5% of stromal cells are viable. Claim 1: The placental product of any of claims 1 - 14, wherein the amniotic Membrane is between approximately 1% and about 10% of MSC.Placental claim 28: the product of any of claims 1 - 14, wherein the amniotic Membrane includes fibroblasts at a ratio of between about 2% and about 30% relative to total cells.Claim 1: The placental product of any of claims 1 - 28Wherein the placenta or amniotic Membrane Product Secret between approximately 0 and approximately 420 pg / ml TNF alpha in the Culture medium of tissue When placed a piece of 2 cm x 2 cm the product in the placental Tissue Culture medium and the product A bacterial lipopolysaccharide in Tissue between approximately 20 and approximately 24 hoRas. Claim 30: placental product of claim 29, wherein such between approximately 0 and approximately 420 pg / ml TNF alpha comprise between approximately 0 and about 350 pg / ml TNF alpha or between 0 and approximately 28
