DERIVES DE PIPERAZINE CONDENSES A BASE DE TRIAZOLE, D'IMIDAZOLE ET DE PYRROLE ET LEUR UTILISATION EN TANT QUE MODULATEURS DES RECEPTEUR DE MGLU5

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专利权人:

RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A

发明人:

GRAZIANI, DAVIDE,RIVA, CARLO,MENEGON, SERGIO,TAZZARI, VALERIO

申请号：

CA3088288

公开号：

CA3088288A1

申请日:

2019.01.17

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

Disclosed are triazole, imidazole and pyrrole condensed piperazine derivatives and their use as allosteric modulators of mGlus receptor activity, pharmaceutical compositions comprising such compounds, and methods of treatment therewith. Compounds of the invention can be used for the treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline, dementia or cognitive impairment, or other pathologies that can be related either directly or indirectly to glutamate dysfunction, i.e., disorders treatable by positive allosteric modulation (PAM) or by negative allosteric modulation (NAM) of mGluR5.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/