A directed liposome comprising: one or more phospholipids, wherein the one or more phospholipids is a phosphatidylcholine, a phosphatidyl ethanolamine derivatized with N - () - dicarboxylic acid, a phosphatidyl ethanolamine derivatized with N - () - dicarboxylic acid modified with a targeting factor, an encapsulated drug or labeled compound and, at least one additional lipid, wherein the at least one additional lipid is cholesterol or a cholesterol derivative, in which the phosphatidyl ethanolamine derivatized with modified N - () - dicarboxylic acid with a targeting factor it comprises a targeting ligand bound to a second phosphatidyl ethanolamine derivatized with N - () - dicarboxylic acid； wherein the addressing factor is present in an amount of 10 to 50μg per mg of lipid； and wherein: phosphatidyl ethanolamine derivatized with N - () - dicarboxylic acid is represented by Formula 1, ** Formula ** and the second phosphatidyl ethanolamine derivatized with N - () - dicarboxylic acid is represented by Formula 3, ** Formula ** in which: R1, R2, R5 and R6 are each, independently, an acyl group, and m and p are, independently, an integer from 1 to 10； and wherein the liposome does not comprise a non-derivatized phosphatidyl ethanolamine, polyethylene glycol or egg phosphatidylcholine, wherein the term "non derivatized phosphatidyl ethanolamine" refers to semisynthetic phosphatidyl ethanolamine, phosphatidyl ethanolamine (s), phosphatidyl ethanolamine (s), synthetic (s) and / or its derivatives that are not covered by the following Formula 1, Formula 2 or Formula 3, ** Formula ** in which: R1, R2, R3, R4, R5 and R6 are each of form independently an acyl group, and m, n, and p are independently an integer from 1 to 10； and in which the targeting ligand is not an intact antibody.Un liposoma dirigido que comprende: uno o más fosfolípidos, en donde el uno o más fosfolípidos es una fosfatidilcolina, una fosfatidil etanolamina derivatizada con ácido N-()-dicarboxílico, una fos
