Hyun Koo;Marlise I. Klein;Megan L. Falsetta Wood;Danielle Benoit
发明人:
Hyun Koo,Danielle Benoit,Marlise I. Klein,Megan L. Falsetta Wood
申请号：
US14768945
公开号：
US20150374634A1
申请日:
2014.02.25
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to compositions and methods to treat and/or prevent biofilms and biofilm related diseases. The invention comprises a nanoparticle carrier (NPC) and at least one therapeutic agent therein. The NPC binds within biofilm and to surfaces at risk for biofilm formation and accumulation while providing local, sustained, enhanced and controlled delivery of the therapeutic agent, when triggered for release. In one embodiment, the NPC comprises pH-responsive elements that allows for specific delivery of the therapeutic agent when the local environment dictates that the agent should be delivered precisely when it is most needed.
