The invention relates to a heart valve prosthesis (100,200,300,400,500) fixed through an interventricular septum (183,383). The heart valve prosthesis (100,200,300,400,500) comprises a valve support (110,210,310) and a fixing device (113,213,313,518). The valve support (110,210,310) comprises a valve sewing section (112,212,312,412,512) and an artificial valve (120, 520), and the artificial valve (120, 520) is fixedly connected on the valve sewing section (112,212,312,412,512)； the fixing device (113,213,313,518) comprises a fixing supporting section (114,214,314, 514) and a fixing piece (115,215,315,415,515), one end of the fixing supporting section (114,214,314, 514) is connected on the end-close part of the valve sewing section (112,212,312,412,512), and the other end of the fixing supporting section (114,214,314, 514) is connected on the interventricular septum (183,383) of a patient through the fixing piece (115,215,315,415,515), supports the heart valve prosthesis (100,200,300,400,500), and limits the heart valve prosthesis (100,200,300,400,500) to axially move.
