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Immunostimulatory oligonucleotides and use thereof in pharmaceuticals
专利权人:
Akiko Soneda;Hideki Narumi;Shizuo Akira;Akihito Kaneda;Tomokatsu Iwamura;Hajime Masumoto
发明人:
Tomokatsu Iwamura,Hideki Narumi,Hajime Masumoto,Akihito Kaneda,Akiko Soneda,Shizuo Akira
申请号:
US12301746
公开号:
US08592566B2
申请日:
2007.05.31
申请国别(地区):
US
年份:
2013
代理人:
摘要:
A novel immunostimulatory oligonucleotide by which an IFN-inducing activity is enhanced and an inflammatory cytokine-inducing activity is reduced, and a pharmaceutical containing the same, and an application thereof are provided. That is, the present invention provides the immunostimulatory oligonucleotide composed of a base sequence represented by a formula: 5′-(G)MPXCGYQ(G)N-3′ (SEQ ID NO: 118) (X and Y are mutually independent and represent an arbitrary sequence which has a length of 0 to 10 nucleotides and does not contain 4 or more consecutive G residues, and a length of X+Y is 6 to 20 nucleotides; XCGY contains a palindrome sequence having a length of at least 8 nucleotides and has a length of 8 to 22 nucleotides; P and Q are mutually independent and represent one nucleotide other than G; M represents an integer of 6 to 10 and N represents an integer of 0 to 3) wherein a full length thereof is 16 to 37 nucleotides (except for an oligonucleotide composed of a base sequence represented by SEQ ID NO:5), the pharmaceutical application thereof.
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