The invention relates to a gem-difluoride glycoconjugated compound withformula (I):where R represents H or a benzyl, acetyl, benzoyl alkyl group, R1 and R2 maybeidentical or different and represent H or an alkyl, benzyl, benzoyl, acetyl,pivaloyl,trialkylsilyl, tertiobutyl- diphenylsilyl protective group or an acetal groupof the CRR"type, where R and R" may be identical or different and represent H or analkyl, aryl,benzyl or thiophene group, R3 represents H or an alkyl, benzyl, benzoyl,acetyl, pivaloyl,trialkylsilyl or tertiobutyldiphenylsilyl protective group, R4 representsOR", NGRGR",N3, or a phthalimide, where R" represents H or an alkyl, benzyl, benzoyle,acetyl,pivaloyl, trialkylsilyl or tertiobutyldiphenylsilyl protective group, GR andGR" may beidentical or different and represent H or an alkyl, benzyl, benzoyl, acetyl,alkyloxycarbonyl, allyloxycarbonyl or benzyloxycarbonyl group, R5 represents afree orprotected hydroxyl group or a halogen, R6 represents H or an alkyl, acetyl,benzyl, PO3Hor PO3Na group. It is applicable to the preparation of compounds that can beusedparticularly for the treatment of cancer.
