The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof)； methods of administering chimeric and hybrid polypeptides comprising Factor VIII； chimeric and hybrid polypeptides comprising Factor VIII； polynucleotides encoding such chimeric and hybrid polypeptides； cells comprising such polynucleotides； and methods of producing such chimeric and hybrid polypeptides using such cells.本發明提供投與因子VIII(經加工之FVIII、單鏈FVIII或其組合)之方法；投與包含因子VIII之嵌合及雜交多肽之方法；包含因子VIII之嵌合及雜交多肽；編碼該等嵌合及雜交多肽之多核苷酸；包含該等多核苷酸之細胞；及使用該等細胞製備該等嵌合及雜交多肽之方法。
