BURNS, Christopher John,DONOHUE, Andrew Craig,FEUTRILL, John Thomas,NGUYEN, Thao Lien Thi,WILKS, Andrew Frederick,ZENG, Jun
申请号：
ES08714386
公开号：
ES2557930T3
申请日:
2008.03.12
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula Ib ** Formula ** wherein Z is independently selected from N and CH； R1 is independently selected from H, halogen, OH, CONHR2, CON (R2) 2, CF3, R2OR2, CN, morpholino, thiomorpholinyl, 1,1-thiomorpholino dioxide, substituted or unsubstituted piperidinyl, substituted or unsubstituted piperazinyl, imidazolyl , substituted or unsubstituted pyrrolidinyl and C1-4 alkylene, wherein the carbon atoms are optionally replaced by NRY and / or O substituted with morpholino, thiomorpholinyl, 1,1-thiomorpholino dioxide, substituted or unsubstituted piperidinyl, substituted piperazinyl or unsubstituted, imidazolyl or substituted or unsubstituted pyrrolidinyl； R2 is substituted or unsubstituted C1-4 alkyl； RY is H or C1-4 alkyl substituted or unsubstituted； R8 is RXCN； RX is substituted or unsubstituted C1-4 alkylene, wherein up to 2 carbon atoms may optionally be replaced by CO, NSO2R1, NRy, CONRy, SO, SO2 or O； R 11 is H or C 1-4 alkyl, wherein the substituents are selected from the group consisting of C 1-4 alkyl, C 3-6 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkylaryl, aryl, heterocyclyl, halo, haloaryl, haloheterocyclyl, hydroxy, C 1-4 alkoxy, aryloxy, carboxy, amino, C 1-6 alkylaryl, arylacyl, heterocyclycyl, acylamino, acyloxy, C 1-6 alkylsulfenyl, arylsulfonyl and cyano； or an enantiomer thereof, a prodrug thereof or a pharmaceutically acceptable salt thereof, wherein the prodrugs are selected from * compounds wherein an amino acid residue or a polypeptide chain of two or more amino acid residues are covalently linked through a peptide bond to a free amino, hydroxy or carboxylic acid group of said compound of formula Ib； * compounds wherein a carbonate, a carbamate, an amide or an alkyl ester are covalently linked to a free amino, amido, hydroxy or carboxylic acid group of said compound of formula Ib through a carbonyl carbon side chain of the prodrug ； and * compounds wherein a free hydroxyl group of said compound of formula Ib is linked through
