SCHAAB, KEVIN MURRAY,夏布 凯文 莫瑞,夏布 凱文 莫瑞,KING, CHRISTOPHER DAVID,金 克力斯多夫 大卫,金 克力斯多夫 大衛,STOCK, NICHOLAS SIMON,史塔克 尼可拉斯 西蒙,史塔克 尼可拉斯 西蒙
申请号：
TW098117221
公开号：
TWI428337B
申请日:
2009.05.22
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
Described herein is the FLAP inhibitor 3-[3-tert-butylsulfanyl- 1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, and pharmaceutically acceptable salts thereof. Also described are methods of preparing the FLAP inhibitor, or a pharmaceutically acceptable salt thereof, including solvates, and polymorphs thereof. Also described herein are pharmaceutical compositions suitable for administration to a ma mmal that include the FLAP inhibitor, or a pharmaceutically acceptable salt thereof, and methods of using such pharmaceutical compositions for treating respiratory conditions or diseases, as well as other leukotriene-dependent or leukotriene mediated conditions or diseases.一種5-脂氧化酶啟動蛋白(5-lipoxygenase-activating protein(FLAP))抑制劑3-[3-硫化第三丁基-1-[4-(6-乙氧-吡啶-3-基)-苯甲基]-5-(5-甲基-吡啶-2-基甲氧)-1H-吲哚-2-基]-2,2-二甲基丙酸(3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid)以及其藥學上可接受之鹽類;包括一製備上述5-脂氧化酶啟動蛋白抑制劑或其藥學上可接受之鹽類、包括溶劑化物、以及其同質異像物之方法;以及包括上述5-脂氧化酶啟動蛋白抑制劑之藥學化合物,或其藥學上可接受之鹽類,其適於施用於一哺乳類;以及使用此藥學化合物治療呼吸症狀或疾病,及其它依賴白三烯素(leukotriene)或白三烯素傳達之症狀或疾病的方法。
