Polyaromatic sodium channel blockers represented by the formula:are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.本發明提供由下式表示之多芳香族鈉通道阻斷劑:其中結構式代號係如本文中定義。本發明亦包括多種組合物、組合及使用該等本發明鈉通道阻斷劑之治療方法。