#$%^&*AU2013200821B220151203.pdf#####ABSTRACT Polyaromatic sodium channel blockers represented by the formula (1): 1 0 NHRI 3 X 6 N 2 ' 1 N=C-N (I) Y N NHR2 4 are provided where the structural variables are defined herein. The invention also includes a variety of compositions, combinations and methods of treatment using these inventive sodium channel blockers.