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PROCESS FOR SYNTHESIS OF A MAGNETIC COMPOSITE
专利权人:
INSTITUTUL DE CHIMIE MACROMOLECULARĂ " PETRU PONI " IAŞI
发明人:
CHIRIAC AURICA,CHIRIAC AURICA,NIŢĂ LOREDANA ELENA,NIŢĂ LOREDANA ELENA,NEAMTU IORDANA,NEAMTU IORDANA,TUDORACHI NIŢĂ,TUDORACHI NIŢĂ,DIACONU ALINA,DIACONU ALINA,BĂLAN VERA,BĂLAN VERA
申请号:
RO201400808
公开号:
RO131027B1
申请日:
2014.10.29
申请国别(地区):
RO
年份:
2017
代理人:
摘要:
The invention relates to a process for preparing a magnetic composite to be used as a magnetic carrier of active substances and as a therapy instrument for targeted delivery and controlled release of medicaments. According to the invention, the process consists in the synthesis of a polymer matrix using 3,9-divinyl-2,4,8,10-tetraoxyspiro[5,5]undecane and maleic anhydride, in a molar ratio of 1:2, in a 22.5% dioxane solution, in the presence of a radical initiator, functionalization thereof by cleaving the maleic cycle within the maleic anhydride, using the reaction with erythritol and preparation of the claimed magnetic composite with magnetite addition, as dispersion or powder, in situ.
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