The present invention provides a compound, or a pharmaceutically acceptable salt or hydrate, and a pharmaceutical composition containing said compound, or a pharmaceutically acceptable salt or hydrate, useful as a Notch pathway signaling inhibitor for the treatment of cancer.本發明提供一種化合物或醫藥可接受鹽或水合物,及含該化合物或醫藥可接受鹽或水合物之醫藥組合物,其適用為治療癌症之刻痕(NOTCH)路徑信號抑制劑。