Methods for treatment of cancer, including hematological malignancies. In particular, the methods include administration of a BTK inhibitor and a BCL-2 inhibitor or pharmaceutically acceptable salts or hydrates thereof, a Btk inhibitor and a Syk inhibitor or pharmaceutically acceptable salts or hydrates thereof, and administration of a Btk inhibitor and a P13K inhibitor or pharmaceutically acceptable salts or hydrates thereof.本文提供治療癌症(包括血液惡性病)之方法。具體而言,該等方法包括BTK抑制劑及BCL-2抑制劑或其醫藥上可接受之鹽或水合物、Btk抑制劑及Syk抑制劑或其醫藥上可接受之鹽或水合物之投與、以及Btk抑制劑及P13K抑制劑或其醫藥上可接受之鹽或水合物之投與。