Disclosed is a production method of a composition with nerve-smoothening and tranquilizing effect, which includes: providing a silk glue made of cocoon and water； diluting the silk glue to obtain a diluted silk glue； mixing a plurality of raw materials to form a precursor mixture, wherein the raw materials include: 1 to 20 parts of the diluted silk glue, 1.5 to 20 parts of kawa extract, 0.5 to 10 parts of [gamma]-aminobutyric acid, 0.1 to 2 parts of tea extract, and 580 to 977.8 parts of water； heating the precursor mixture to reach a temperature of 90 DEG to 100 DEG C so as to obtain a heated precursor mixture； adding a flavoring agent to the heated precursor mixture so as to form a mixture, wherein the flavoring agent contains 10 to 100 parts of fruit juice； and finally cooling down the mixture to reach the room temperature so as to obtain a composition with nerve-smoothening and tranquilizing effects.一種具有安神鎮靜效果的組成物的製造方法，包括提供一蠶絲膠水，其中該蠶絲膠水係由繭殼與水製成；稀釋該蠶絲膠水以取得一經稀釋的蠶絲膠水；混合複數原料以形成一前驅混合物，其中該些原料包括：1~20份的經稀釋的蠶絲膠水、1.5~20份的卡瓦萃取物、0.5~10份的γ-氨基丁酸、0.1~2份的茶葉萃取物以及580~977.8份的水；加熱該前驅混合物至90~100℃以取得一經加熱的前驅混合物；添加一調味劑至該經加熱的前驅混合物而形成一混合物，其中該調味劑包括10~100份的果汁；以及冷卻該混合物至室溫而取得該具有安神鎮靜效果的組成物。
