KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
发明人:
KIM, Yoonkyung,김윤경,KIM, Dong-Eog,김동억,JUNG, Hye-Youn,정혜연,CHOE, Yun Hui,최윤희
申请号：
KRKR2011/006002
公开号：
WO2012/021046A3
申请日:
2011.08.16
申请国别(地区):
WO
年份:
2012
代理人:
摘要：
The present invention relates to a radial shape of a polymer compound containing iodine capable of being used as an active ingredient of a CT contrast medium, a preparation method thereof, and a contrast medium composition containing the same. According to the present invention, the radial shape of the polymer compound containing iodine has a remarkably enhanced contrast effect retention time compared with a conventional low molecular weight contrast medium compound containing iodine. In addition, the polymer compound containing iodine forms a protective film by encompassing a compound containing iodine substituted near the surface of a central nucleus, which leaves room for causing various kinds of abnormal reactions with toxicity, with a relatively long biocompatible polymer chain layer, thereby preventing the exposure thereof to external environments to reduce in vivo toxicity, preventing the rapid absorption due to a macrophage to extend in vivo circulation time, and allowing the polymer compound containing iodine to be discharged from the body after an adequate time has passed since an in vivo injection. Further, the preparation method and the purification method of the polymer compound containing iodine are very simple, thereby enabling mass production in a high yield and at low costs, the polydispersity is very low, thereby providing high reproducibility in the preparation and effects, and all of the structures of the prepared radial shape of the polymer compound containing iodine comprise a covalent bond, thereby being structurally very stable, and thus the polymer compound containing iodine can be useful for the preparation of a CT contrast medium.La présente invention concerne une forme radiale dun composé polymère contenant de liode pouvant être utilisée en tant que substance active dun agent de contraste TDM, un procédé de préparation de celui-ci, et une composition dagent de contraste contenant celle-ci. Selon la présente invention, la forme radiale du
