BODICK NEIL,BLANKS ROBERT C.,KUMAR ANJALI,CLAYMAN MICHAEL D.,MORAN MARK
申请号：
NZ60779711
公开号：
NZ607797A
申请日:
2011.08.04
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Provided are corticosteroid microparticle formulations wherein a corticosteroid is incorporated in a lactic acid-glycolic acid copolymer matrix in the microparticle. These are of use in the treatment of joint pain. A preferred embodiment is a formulation comprising (a) controlled- or sustained-release microparticles comprising a Class B corticosteroid and a poly(lactic-co-glycolic) acid copolymer (PLGA) matrix, wherein the Class B corticosteroid comprises between 22% to 28% of the microparticles and wherein the PLGA has the following characteristics: (i) a molecular weight in the range of about 40 to 70 kDa and (ii) a lactide:glycolide molar ratio of 80:20 to 60:40. A preferred Class B corticosteroid is triamcinolone acetonide.
