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Stabilization of proteins in solution
专利权人:
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト
发明人:
ジェンセン、マイケル・ベック,ハンセン、ビルテ・リッケガールド,コルンフェルト、トロエルス,ヤコブセン、キルステン・クラマー
申请号:
JP2006529638
公开号:
JP5627832B2
申请日:
2004.05.21
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
Provided are storage containers for proteinaceous pharmaceutical compositions which are characterized in, among other things, comprising (i) a wall portion, wherein an inner wall material thereof is selected from silica-coated glass, silicone-coated glass, polymers of non-cyclic olefins, cycloolefin polymers and cycloolefin/linear olefin copolymers and (ii) one or more closure portions not constituting part of the wall portion, and which contains a formulation of a protein. Also provided are new methods of storing proteinaceous compositions. In one aspect, the stored protein is characterized as having an amino-terminal gamma-carboxyglutamic acid (Gla) domain with 9-12 Gla residues.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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