compound, pharmaceutical composition, glucokinase activating agent, hypoglycemic agent, agent for preventing and / or treating at least one disease, methods for activating glucokinase, for lowering blood glucose level and for preventing and / or treating at least one disease , and, use of a compound

• 收藏
• 分享

专利权人:

KOWA COMPANY; LTD.

发明人:

Shin Tanikawa,Shinsuke Itoh,Takahisa Ogamino,Yoshiharu Miyake,Yoshizaku Sawada

申请号：

BR112015005631

公开号：

BR112015005631A2

申请日:

2013.09.25

申请国别(地区):

BR

年份:

2017

代理人:

摘要：

1/1 summary “compound, pharmaceutical composition, glucokinase activating agent, hypoglycemic agent, agent to prevent and / or treat at least one disease, methods to activate glucokinase, to decrease blood glucose and to prevent and / or treat at least one disease, and use of a compound is the purpose of the invention to create a compound that selectively activates glucokinase in the ventilator and, in in particular, to provide a drug having a low hypoglycemic risk for the treatment and prevention of diabetes and impaired glucose tolerance. a compound represented by the general formula (1) [in the formula (1), ring a shows a thiazolyl group, pyridyl group, pyrazyl group, or pyrazolyl group； 1 shows - (co) -, - (cs) -, or 1 -so -； and r shows an alkyl group, hydroxy and alkyl group, c 2-6 1-6 1- alkoxy group, amino group, alkylamino group, hydroxyamino group, n-6 1-6 3 alkylcarbamoyl group, or group represented by of formula (2), r shows here 1-6 an alkyl group； r shows a hydrogen atom, 1-6 halogen atom, c-alkyl group, c-alkoxy group, or carboxyl group] or a 1-6 1-6 salt thereof or a solvate thereof.1 / 1 resumo “composto, composiã‡ãƒo farmacãšutica, agente de ativaã‡ãƒo de glucoquinase, agente hipoglicãšmico, agente para prevenir e/ou tratar pelo menos uma doenã‡a, mã‰todos para ativar glucoquinase, para diminuir o nã�vel de glicose no sangue e para prevenir e/ou tratar pelo menos uma doenã‡a, e, uso de um compostoâ€� a finalidade de invenã§ã£o ã© para criar um composto que seletivamente ativa glucoquinase no fã­gado e, em particular, para fornecer uma droga tendo um risco hipoglicãªmico baixo para o tratamento e prevenã§ã£o de diabetes e tolerã¢ncia a glicose prejudicada. um composto representado pela fã³rmula geral (1) [na fã³rmula (1), o anel a mostra um grupo tiazolila, grupo piridila, grupo pirazila, ou grupo pirazolila； l mostra -(co)-, -(cs)-, ou 1 -so -； e r mostra um grupo c alquila, grupo hidrã³xi c alquila, grupo c 2 1-6 1-6 1- alcã³xi, grupo amino, gru

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/