COMPOSITIONS PHARMACEUTIQUES COMPRENANT DES INHIBITEURS DE NEUROPILINE, ET LEUR UTILISATION DANS LA PREVENTION ET/OU LE TRAITEMENT DE TROUBLES ANGIOGENIQUES ET DE CANCERS
The present invention relates to a compound of general formula (I), wherein Z1 is S or O, preferably S； -Z2- is -NRa-, wherein Ra is H, OH, alkyl, alkoxy, aryle, alkenyl, alkynyl, amine, preferably Ra is H； -N=； O； S； -CRb=, wherein Rb is H, OH, alkyl, alkoxy, aryle, alkenyl, alkynyl, amine, NO2, C1, Br, I, F, preferably H； -CHRC- wherein Rc is H, OH, alkyl, alkoxy, aryle, alkenyl, alkynyl, amine, NO2, C1, Br, I, F, or -CH2-； preferably -Z2- is -NH- or -N=； each of R1 and R2 independently is H, OH, alkyl, alkoxy, aryle, alkenyl, alkynyl, amine, NO2, C1, Br, I, F； preferably R1 and R2 together and with N and Z2 form an heterocycle eventually substituted, provided that said heterocycle is not an indole； R5 is H, OH, C1-4 alkyl, C1-4 alkoxy, C1-4 alkenyl, C1-4 alkynyl, amine, preferably R5 is NH2, NO2, C1, F, Br, I； more preferably R5 is H or CH3； even more preferably R5 is CH3； each of R8 and R9 independently is, H, OH, alkyl, alkoxy, aryle, alkenyl, alkynyl, amine, NO2, C1, Br, I, F； preferably R8 and R9 together form a cycle comprising 5 or 6 atoms, preferably an heterocycle comprising 5 or 6 atoms, more preferably a 1,3- dioxacyclopentene or a 1,4-dioxane； and - each of R3, R4, R6, R7, R10 and R11 independently is, H, OH, C1-4 alkyl, C1-4 alkoxy, C1-4 alkenyl, C1-4 alkynyl, amine, NO2, F, C1, Br, I； preferably H, CH3, OCH3, OH, NH2, NO2, C1, F, Br, I； more preferably is H or CH3； even more preferably is H； and to a pharmaceutical composition comprising a compound of general formula (I) or esters or salts thereof, in association with at least one pharmaceutically acceptable vehicle； and to the use thereof for inhibiting the Neuropilin pathways in the treatment of cancer and of angiogenic diseases.
