БАРБАРА Рональд (FR),ОНИСИЮ Даниела Кармен (FR),ДАССЕ Жан-Луи (FR),СКОТТ Роберт А. (FR),ВЕТТЕРО Джон Р. (US)
申请号：
RU2012109545/15
公开号：
RU2012109545A
申请日:
2010.08.13
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A method of treating lung diseases selected from the group consisting of chronic obstructive airways disease (COAD), chronic obstructive pulmonary disease (COPD), adolescent asthma, emphysema or adolescent asthma, comprising administering a compound of formula (I) or a salt thereof : where R is phenyl, naphthyl, pyridyl, thienyl, furyl, quinolyl or benzothienyl, any of which may have substituents selected from the group consisting of C1-6 alkyl, C1-6 alkyl containing halogen, C1-4 alkoxy, C1-4 alkoxy containing halogen n, Calkenyl, Calkynyl, halogen, Cacyl, benzoyl, hydroxyl, nitro, amino, phenyl and pyridyl； R is C 1-6 alkyl, C 1-6 alkyl containing halogen, C 2-6 alkenyl, C 2-6 membered cycloalkyl, 3-7 membered C 1-6 alkyl cycloalkyl, or C1-6alkyl substituted with phenyl, naphthyl or pyridyl, any of which may have substituents selected from the group consisting of C1-6alkyl, C1-6alkyl containing halogen, C1-6 alkoxy, C1-4 alkoxy, containing halogen, C1-6alkenyl, C1-6alkyl, halogen, 1-4 acyl, benzoyl, hydroxyl , nitro, amino, phenyl and pyridyl； A represents co oxygen, sulfur or NR, where R represents hydrogen or C 1-6 alkyl； X represents a C 1-6 alkylene chain which may have substituents selected from the group consisting of C 1-6 alkyl, C 1 alkoxy and hydroxyl, and which may contain a double bond； Y represents C (= O), C (= N-OR), CH (OR), CH = CH, CC, or C (= CH), where each of R and R represents hydrogen or C1-6 alkyl； each of R, R and R represents hydrogen, C1-6 alkyl, Calkyl containing halogen, Calkoxy, Calkoxy containing halogen, Calkenyl, Calkynyl, halogen, Cacyl, benzoyl, hydroxyl, nitro, amino, phenyl or pi1. Способ лечения заболеваний легких, выбранных из группы, состоящей из хронического обструктивного заболевания дыхательных путей (COAD), хронического обструктивного заболевания легких (COPD), астмы зрелого возраста, эмфиземы или астмы юношеского возраста, включающий введение соединения формулы (I) или его соли:где Rпредставляет собой фенил, нафтил, п
